Related Experiment Video
Updated: Jan 31, 2026
05:42
Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation
Published on: April 7, 2023
1.2K
Calcium Microcrystal Formation in Recurrent Herniation Patients After Autologous Disc Cell Transplantation
S Schwan1,2, C Ludtka1,2,3, A Friedmann1,2
11Translational Centre of Regenerative Medicine TRM, University of Leipzig, Philipp-Rosenthal-Straße 55, 04103 Leipzig, Germany.
Tissue Engineering and Regenerative Medicine
|January 4, 2019
Summary
Autologous disc cell transplantation (ADCT) in patients with recurrent disc herniation was associated with calcium microcrystal formation, suggesting potential disc degradation. Further research is needed to understand ADCT
Area of Science:
- Regenerative Medicine
- Orthopedics
- Cell-based Therapies
Background:
- Autologous disc cell transplantation (ADCT) aims to regenerate intervertebral disc (IVD) tissue.
- Potential risks and structural changes following ADCT are not well understood.
- This study investigates structural phenomena post-ADCT in IVD disease.
Purpose of the Study:
- To investigate structural phenomena associated with autologous disc cell transplantation (ADCT) in patients with intervertebral disc (IVD) disease.
- To compare tissue samples from ADCT-treated patients with recurrent herniation to conventionally-treated and first-time herniation patients.
- To identify potential risks and understand transformation processes after ADCT.
Main Methods:
- Tissue samples obtained via micro-sequestrectomy from ADCT-treated and control groups.
- Analysis using micro-computed tomography, scanning electron microscopy, and energy dispersive spectroscopy.
- Histological evaluation of calcification, tissue structure, cell density, morphology, and elemental composition.
Main Results:
- Calcium microcrystal formation was identified in all ADCT-treated samples, absent in controls.
- Magnesium-containing calcium phosphate was detected in mineral particles.
- These findings suggest potential disc degradation associated with ADCT.
Conclusions:
- Calcium microcrystal formation is a unique structural phenomenon observed in ADCT-treated herniated discs.
- Findings suggest ADCT may be linked to disc degradation, warranting further investigation.
- Limitations include the absence of a control group of ADCT patients without recurrent herniation.
Related Concept Videos
01:31Formation of Species
45.1K
Speciation describes the formation of one or more new species from one or sometimes multiple original species. The resulting species are discrete from the parent species, and barriers to reproduction will typically exist. There are two primary mechanisms, speciation with and without geographic isolation—allopatric and sympatric speciation, respectively.
45.1K
01:10Zygotic Development And Stem Cell Formation
6.7K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
6.7K
02:16Solution Formation
37.5K
There is no one solvent that can dissolve every type of solute. Some substances that readily dissolve in a certain solvent might be insoluble in a different solvent. A simple way to predict which substances dissolve in which solvent is the phrase "like dissolves like". This means that polar substances, such as salt and sugar, dissolve in a polar substance like water. In contrast, non-polar substances are more soluble in non-polar solvents such as carbon tetrachloride.
This selective...
This selective...
37.5K
02:37Standard Enthalpy of Formation
49.2K
Enthalpy changes are typically tabulated for reactions in which both the reactants and products are at the same conditions. A standard state is a commonly accepted set of conditions used as a reference point for the determination of properties under other different conditions. For chemists, the IUPAC standard state refers to materials under a pressure of 1 bar and solutions at 1 M and does not specify a temperature. Many thermochemical tables list values with a standard state of 1 atm. Because...
49.2K
03:45Formation of Complex Ions
26.1K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.1K
01:17Design Example: Calculating Safe Diameter for Wind-Exposed Disc
358
Assessing safety in wind-exposed installations is crucial to preventing potential failures. This example explores the calculation and design adjustments needed to mount a circular disc on a building facade, where wind forces are a primary concern. A 4-meter diameter disc was initially designed as an aesthetic feature facing winds at a velocity of 25 meters per second, with an air density of 1.25 kilograms per cubic meter. Given these conditions, the drag force on the disc was determined using...
358