Related Experiment Videos
Thioredoxin from activated macrophages as a trophic factor for central cholinergic neurons in vitro
M Endoh1, T Kunishita, T Tabira
1Division of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Biochemical and Biophysical Research Communications
|April 30, 1993
Abstract:
The conditioned medium from gamma-interferon-stimulated macrophages elevated the choline acetyltransferase activity in mouse septal neurons as well as in cholinergic hybrid cell lines SN6.10.2.2 in vitro. After purification and sequencing, the active fraction was identical to thioredoxin (TRX), and the neurotrophic activity of recombinant TRX was confirmed.