[Thermodynamic and spectroscopic study of complex formation of dipeptides with dimethyl sulfoxide in their aqueous solutions]

Peculiarities of intermolecular interactions in water-dimethylsulfoxide solutions of dipeptides-glycyl-glycine, beta-alanyl-glycine, beta-alanyl-beta-alanine, DL-alpha-alanyl-DL-alpha-alanine, DL-alpha-alanyl-DL-valine-were analysed on the basis of thermodynamic characteristics and data on IR-spectra. Dimethylsulfoxide additions were shown to cause destruction of peptide associates present in aqueous solutions due to the formation of stronger bonds "peptide-DMSO". The existence of complexes between dimethylsulfoxide and beta-alanyl-glycine, beta-alanyl-beta-alanine, DL-alpha-alanyl-DL-alpha-alanine was found. The mechanism of their formation was determined by the dipeptide structure.