Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The transferrin receptor

U Testa1, E Pelosi, C Peschle

  • 1Department of Hematology and Oncology, Istituto Superiore di Sanità, Rome, Italy.

Critical Reviews in Oncogenesis
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

18F-FDG PET/CT in the post-operative monitoring of patients with adrenocortical carcinoma.

European journal of endocrinology·2015
Same author

A miRNA Signature in Human Cord Blood Stem and Progenitor Cells as Potential Biomarker of Specific Acute Myeloid Leukemia Subtypes.

Journal of cellular physiology·2014
Same author

A candidate anti-HIV reservoir compound, auranofin, exerts a selective 'anti-memory' effect by exploiting the baseline oxidative status of lymphocytes.

Cell death & disease·2013
Same author

Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors.

Cell death and differentiation·2013
Same author

PET in the clinical work-up of patients with spondylodiscitis: a new tool for the clinician?

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2013
Same author

MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias.

Blood cancer journal·2012
Same journal

Transcription Factor and Tumorigenesis: Perspectives and Concluding Remarks.

Critical reviews in oncogenesis·2026
Same journal

Review Article: Intratumoral Immunotherapy: Old Discoveries and Recent Developments in Sarcomas.

Critical reviews in oncogenesis·2026
Same journal

Review Article: Dynamin-Related Protein 1 in Cancer Progression: Mechanisms and Implications.

Critical reviews in oncogenesis·2026
Same journal

Review Article: EZH2 in Pancreatic Cancer: Epigenetic Driver and Therapeutic Target.

Critical reviews in oncogenesis·2026
Same journal

Review Article: YY2 in Tumor Regulation: Core Mechanisms and Functional Networks.

Critical reviews in oncogenesis·2026
Same journal

Review Article: Decoding the Role of PBX3 in Cancer: Molecular Mechanisms and Therapeutic Strategies.

Critical reviews in oncogenesis·2026
See all related articles

Iron regulates transferrin receptor (TfR) expression via the iron-regulatory element (IRE) and IRE-binding protein (IRE-BP). Understanding IRE-BP activity is key to modulating TfR in normal and cancer cells.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Transferrin receptor (TfR) controls cellular iron uptake, essential for cell proliferation via ribonucleotide reductase.
  • TfR is overexpressed in various tumors, highlighting its role in cancer.
  • TfR synthesis is regulated by iron-dependent feedback mechanisms, differing between proliferating and iron-storing cells.

Purpose of the Study:

  • To elucidate the molecular mechanisms of iron-regulated TfR expression.
  • To investigate the role of the iron-regulatory element (IRE) and IRE-binding protein (IRE-BP) in TfR regulation.

Main Methods:

  • Analysis of the 3' untranslated region of TfR mRNA.
  • Study of the interaction between IRE and IRE-binding protein (IRE-BP).

Related Experiment Videos

Main Results:

  • The 3' untranslated region of TfR mRNA contains an iron-regulatory element (IRE).
  • IRE interacts with IRE-binding protein (IRE-BP).
  • This interaction represses TfR mRNA degradation, increasing TfR synthesis.

Conclusions:

  • Iron regulation of TfR expression is mediated by the IRE-IRE-BP interaction.
  • Studying IRE-BP activity is crucial for understanding TfR modulation in normal and malignant cells.