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Mitochondrial abnormalities in progressive external ophthalmoplegia
American Journal of Ophthalmology
|March 1, 1977
Summary
Chronic progressive external ophthalmoplegia is linked to abnormal mitochondria in muscle fibers. These mitochondrial defects may cause widespread metabolic issues, suggesting a diffuse mitochondrial disease.
Area of Science:
- Neurology
- Mitochondrial Biology
- Muscle Physiology
Background:
- Chronic progressive external ophthalmoplegia (CPEO) is a rare neuromuscular disorder.
- Ragged-red fibers are a histological hallmark observed in muscle biopsies of patients with mitochondrial myopathies.