Lipid peroxidation on dialysis membranes

The aim of this study was to compare the changes of lipid peroxidation during haemodialysis (HD), using various types of dialyser membranes. A significantly higher concentration of total and free TBARS (thiobarbituric acid reacting substance) was found in blood and in plasma of HD patients, compared with the control group of blood donors. During the HD session the TBARS levels grow significantly, compared to the initial levels on both membranes (Alpha 500, Pro500), and are significantly higher after 15 min of HD on Alpha 500 membrane. The levels of TBARS appear to be significantly higher in patients on regular HD treatment, which may be due to a more intensive lipid peroxidation. There were significant acute changes in lipid peroxidation during one HD session. The changes in lipid peroxidation differ with the use of various HD membranes.