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Analysis of multivariate parallel-line bioassay with composite responses and composite doses, using canonical
1Department of Biostatistics, University of Michigan, Ann Arbor.
Journal of Biopharmaceutical Statistics
|March 1, 1993
Abstract:
The use of a composite response to estimate the relative potency in a multivariate parallel-line bioassay is described by Finney. Occasionally a multivariate bioassay has multiple drugs also. Such a situation arises, for example, when a treatment contains several drugs. A procedure for combining multiple responses and combining multiple drugs is proposed in this paper, in order to obtain point and interval estimates of the relative potency. A composite response and a composite dose level for this purpose are obtained by using canonical analysis.