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Postsynaptic supersensitivity in schizophrenia

G N Pandey, D L Garver, C Tamminga

    The American Journal of Psychiatry
    |May 1, 1977
    PubMed
    Summary
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    Acute schizophrenia patients show heightened dopamine receptor sensitivity, indicated by increased growth hormone release and adenylate cyclase activity compared to chronic patients and controls.

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Endocrinology

    Background:

    • The dopamine hypothesis of schizophrenia suggests altered dopaminergic neurotransmission.
    • Postsynaptic dopamine (DA) receptor sensitivity is a key area of investigation.

    Purpose of the Study:

    • To investigate postsynaptic DA receptor sensitivity in schizophrenia using a neuroendocrine approach.
    • To correlate receptor sensitivity with clinical presentation and enzyme activity.

    Main Methods:

    • Utilized apomorphine, a DA receptor agonist, to measure growth hormone (GH) release as a postsynaptic event.
    • Assessed platelet adenylate cyclase activity, linked to catecholamine receptor function, after prostaglandin E1 stimulation.

    Main Results:

    Related Experiment Videos

  • Acute schizophrenia patients exhibited significantly higher GH responses to apomorphine compared to chronic patients and controls.
  • Elevated adenylate cyclase activity was observed in acute schizophrenia patients.
  • Chronic schizophrenic patients, with or without tardive dyskinesia, showed no significant difference in GH response compared to controls.

    • Conclusions:

    • Findings suggest increased postsynaptic DA receptor sensitivity in acute schizophrenia.
    • The neuroendocrine strategy provides a viable method for assessing DA receptor function in schizophrenia.