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Fetal C-reactive protein

P J Thompson1, A Greenough, E Davies

  • 1Department of Child Health, King's College Hospital, London, UK.

Early Human Development
|March 1, 1993
PubMed
Summary
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Elevated fetal C-reactive protein (CRP) levels may indicate infection in fetuses experiencing preterm prelabour rupture of membranes (PPROM). This finding could aid in early detection and management of fetal infections.

Area of Science:

  • Perinatal Medicine
  • Immunology
  • Biochemistry

Background:

  • Preterm prelabour rupture of membranes (PPROM) is a significant obstetric complication.
  • Fetal infection is a serious risk associated with PPROM.
  • Accurate and early detection of fetal infection is crucial for timely intervention.

Purpose of the Study:

  • To investigate the utility of fetal C-reactive protein (CRP) as an indicator of infection in pregnancies complicated by PPROM.
  • To establish reference levels of fetal CRP in healthy term infants.

Main Methods:

  • Fetal blood samples were collected via cordocentesis from 17 patients with PPROM.
  • C-reactive protein (CRP) levels were measured in fetal blood.
  • CRP levels in fetuses with PPROM were compared to those in healthy term infants.

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Main Results:

  • CRP was detected in 8 out of 17 fetuses with PPROM.
  • Six fetuses with elevated CRP levels (>= 0.8 mg dl-1) showed signs suggestive of infection.
  • Healthy term infants had significantly lower CRP levels (< 0.6 mg dl-1).

Conclusions:

  • Elevated fetal CRP levels may serve as a valuable biomarker for detecting fetal infection in cases of PPROM.
  • This finding supports the potential use of fetal CRP testing for improved perinatal care and management of PPROM.