Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nutrient bioavailability, with special reference to calcium

F Bronner1

  • 1Department of BioStructure and Function, University of Connecticut Health Center, Farmington 06030.

The Journal of Nutrition
|May 1, 1993
PubMed
Summary

Nutrient bioavailability is complex, involving many hard-to-measure metabolic steps. Factors like age, pregnancy, and nutrition significantly impact nutrient absorption, requiring extensive research for accurate evaluation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Post-denervation renal artery stenosis - a matter of concern?].

Annales de cardiologie et d'angeiologie·2015
Same author

[About an implantable cardioverter-fibrillator].

Annales de cardiologie et d'angeiologie·2011
Same author

An analysis of the role and function of educational reconditioning; with particular reference to the program at Welch Convalescent Hospital.

Occupational therapy and rehabilitation·2010
Same author

A Symbolic Model for the Regulation by Bone Metabolism of the Blood Calcium Level in Rats.

Biophysical journal·2009
Same author

Extracellular and intracellular regulation of calcium homeostasis.

TheScientificWorldJournal·2003
Same author

Circulating adrenomedullin is increased after renal transplantation.

Transplantation proceedings·2001

Area of Science:

  • Nutritional Science
  • Biochemistry
  • Physiology

Background:

  • Bioavailability encompasses multiple metabolic processes: digestibility, solubilization, absorption, organ uptake/release, transformation, secretion, and excretion.
  • These processes are challenging to measure experimentally and are influenced by age, nutrition, and hormones.
  • Calcium bioavailability is particularly complex due to age-related demand changes and physiological states like pregnancy and lactation.

Purpose of the Study:

  • To analyze the multifaceted nature of nutrient bioavailability.
  • To highlight the complexities and age-dependencies in nutrient absorption, using calcium as a case study.
  • To discuss the research required to establish bioavailability as a quantitative concept.

Main Methods:

  • Review of existing literature on nutrient metabolism and bioavailability.
  • Analysis of factors influencing calcium absorption, including passive and regulatable components.
  • Discussion of experimental challenges in measuring individual metabolic steps.

Main Results:

  • Bioavailability is a composite of numerous, often interdependent, physiological and metabolic events.
  • Calcium absorption is significantly affected by age, pregnancy, and lactation, influencing both regulatable and passive components.
  • Accurate quantification of bioavailability requires understanding nutrient pool size, turnover, and external influences like diet and endocrine status.

Conclusions:

  • The concept of bioavailability is currently difficult to quantify due to the complexity of its constituent metabolic events.
  • Significant research is needed to develop reliable methods for measuring bioavailability across different physiological states and life stages.
  • Establishing bioavailability as a quantitative measure is crucial for effective clinical, nutritional, and managerial applications.

Related Experiment Videos