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[Antitoxoplasmic immunity on congenitally athymic nude mice]
Annales D'Immunologie
|January 1, 1977
Summary
Nude mice showed similar susceptibility to toxoplasmic infection as controls. Vaccination offered incomplete immunity, delaying mortality in some cases, with partial cellular and humoral immune responses observed in these mice.
Area of Science:
- Immunology
- Infectious Diseases
- Microbiology
Context:
- Toxoplasmosis is a significant opportunistic infection, particularly in immunocompromised individuals.
- Nude mice (nu/nu) are commonly used models for studying immune responses due to their T-cell deficiency.
Purpose:
- To investigate the susceptibility and immune response to Toxoplasma gondii infection in Nude mice.
- To evaluate the efficacy of vaccination against toxoplasmosis in an immunocompromised mouse model.
Summary:
- Nude mice exhibited comparable susceptibility to toxoplasmic infection as control mice.
- Vaccination with an avirulent Toxoplasma strain provided incomplete protection, delaying mortality in 20-40% of Nude mice.
- Partial cellular (macrophage activation) and humoral (antibody production) immune responses were detected in vaccinated Nude mice.
Impact:
- This study highlights the partial reconstitution of immune responses in Nude mice, suggesting a role for innate immunity and residual adaptive components in controlling Toxoplasma gondii.
- Findings contribute to understanding host-pathogen interactions in T-cell deficient models and inform strategies for managing toxoplasmosis in immunocompromised populations.