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[Abnormal specificities of immune alloantisera]

G Dorval, G Klein, H Wigzell

    Annales D'Immunologie
    |January 1, 1977
    PubMed
    Summary
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    Repeatedly immunized sera contain IgG targeting syngenic tumor cells, indicating an active immunization process against tumor-associated determinants. These anomalous IgG antibodies are crucial for understanding tumor immunology and potential therapeutic targets.

    Area of Science:

    • Immunology
    • Oncology
    • Cell Biology

    Context:

    • Repeated immunization with allogeneic lymphocytes generates sera containing IgG antibodies.
    • These IgG antibodies exhibit high reactivity with syngeneic tumor cells, a response that appears paradoxical compared to specific anti-H-2 immune responses.
    • This reactivity suggests an active immunization process directed against tumor-specific antigens.

    Purpose:

    • To investigate the nature of IgG antibodies found in sera from repeatedly immunized animals.
    • To characterize the tumor-associated determinants targeted by these "anomalous" IgG antibodies.
    • To determine the expression profile of these determinants on various cell types.

    Summary:

    • Sera from animals repeatedly immunized with allogeneic lymphocytes contain IgG antibodies that bind strongly to syngeneic tumor cells.

    Related Experiment Videos

  • Selective absorption studies reveal that the majority of these IgG antibodies are directed against tumor cell membrane components.
  • These tumor-associated determinants are not detected on normal embryonic or adult tissues but are highly expressed on murine malignant cell lines and, to a lesser extent, on maintained tumors.

    • Impact:

    • Elucidates the presence and targets of "anomalous" IgG in tumor immunology.
    • Identifies potential tumor-associated determinants for further investigation.
    • Highlights the differential expression of these determinants, suggesting their potential as specific biomarkers or therapeutic targets in cancer research.