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[Multiple expressions of mouse peritoneal cell immune potential]
Annales D'Immunologie
|January 1, 1977
Abstract:
Peritoneal cells (PC) from unstimulated mice are able to form a high number of rosettes (RFC) (20 to 50%) with sheep red blood cells (SRBC) or bromelin treated isologous mouse red blood cells (MRBC(b)). In culture, this population develops a high number of plaque forming cells (PFC) against SRBC and MRBC(b) with a maximum at day 3-4, while the number of RFC decreases in such a way that the total number of RFC + PFC remains constant. The significance of such results is discussed. Evidence is provided, by the use of radioactive labelling, that IgM antibodies and different sub-classes of IgG are synthesized in vitro by PC during culture.