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Related Experiment Videos

Human growth hormone and human aging

E Corpas1, S M Harman, M R Blackman

  • 1Endocrinology Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

Endocrine Reviews
|February 1, 1993
PubMed
Summary
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Aging reduces growth hormone (GH) and IGF-I, impacting body composition. GH therapy in deficient adults improves lean mass but long-term safety needs more research.

Area of Science:

  • Endocrinology
  • Gerontology
  • Metabolic Research

Background:

  • Aging and growth hormone (GH) deficiency decrease protein synthesis, lean body mass, and bone mass, while increasing body fat.
  • Healthy aging is linked to reduced GH secretion and lower levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3).

Purpose of the Study:

  • To investigate the contribution of age-related changes in GH and IGF-I to body composition and function.
  • To evaluate the effects of GH treatment in GH-deficient adults and older men with low IGF-I.
  • To explore alternative therapeutic approaches like GHRH administration.

Main Methods:

  • Review of existing literature on GH and IGF-I in aging and deficiency states.
  • Analysis of studies involving exogenous GH administration in GH-deficient adults and older men.

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  • Consideration of GHRH as a potential therapeutic agent for maintaining pulsatile GH secretion.

    • Main Results:

    • GH treatment in deficient adults increases IGF-I, nitrogen retention, and lean body mass, while decreasing body fat.
    • GH therapy shows minimal impact on bone mineral density and requires careful dosing to minimize short-term adverse effects.
    • Long-term safety of GH supplementation regarding metabolic abnormalities and malignancy risk remains uncertain.

    Conclusions:

    • GH therapy can improve body composition in GH-deficient adults and older men with low IGF-I.
    • Further research is needed to determine the long-term safety and efficacy of GH and IGF-I normalization in healthy older individuals.
    • GHRH administration presents a potential physiological approach to therapy by maintaining pulsatile GH secretion.