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Glomerular extracellular matrices and anionic sites in aging ddY mice: a morphometric study

H J Duan¹, T Nagata

¹Department of Anatomy and Cell Biology, Shinshu University School of Medicine, Matsumoto, Japan.

|March 1, 1993

Summary

Aging in male ddY mice shows increased glomerular extracellular matrices, including thickened glomerular basement membranes and nodules. However, the number of glomerular anionic sites remained unchanged with age.

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Area of Science:

Nephrology
Gerontology
Pathology

Background:

Aging is associated with progressive kidney damage.
Glomerular changes are key indicators of kidney aging.

Purpose of the Study:

To investigate age-related changes in glomerular ultrastructure and anionic sites in male ddY mice.
To compare age-related glomerular changes in mice with those previously reported in rats.

Main Methods:

Morphometric analysis of glomeruli from mice of various ages.
Examination of glomerular basement membrane (GBM) thickness, GBM nodules, mesangial matrix, and anionic sites using electron microscopy.

Main Results:

Progressive increase in glomerular extracellular matrices, including GBM thickening, GBM nodules, and mesangial matrix expansion, correlated with age.

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Distinct GBM nodules were observed, differing in extent from rat models.

No significant changes in the number of glomerular anionic sites were found across age groups.

Conclusions:

Male ddY mice exhibit age-related increases in glomerular extracellular matrices, similar to rats but with distinct features.
These matrix accumulations occur without significant alterations in glomerular anionic site density.
Glomerular anionic sites may not be a primary target of age-related matrix accumulation in mice.