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Differential binding of tioconazole enantiomers to hydroxypropyl-beta-cyclodextrin studied by capillary
S G Penn1, D M Goodall, J S Loran
1Department of Chemistry, University of York, UK.
Journal of Chromatography
|April 23, 1993
Abstract:
Capillary electrophoresis has been used to determine binding constants of tioconazole enantiomers with hydroxypropyl-beta-cyclodextrin (HP-beta-CD), after correcting for changes in mobility with increasing viscosity. The predicted and observed values of enantiomeric mobility difference were found to be maximum at a concentration of HP-beta-CD equal to the reciprocal of the average binding constant.