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Interaction of ibuprofen with early chick embryogenesis
1Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic.
Die Pharmazie
|March 1, 1993
Summary
Ibuprofen (1) can cause growth retardation in chick embryo caudal systems. Higher doses may lead to embryotoxicity, but severe developmental defects are rare in this model.
Area of Science:
- Developmental biology
- Toxicology
- Pharmacology
Background:
- Ibuprofen is a common nonsteroidal anti-inflammatory drug.
- Assessing drug safety during embryonic development is crucial.
Purpose of the Study:
- To evaluate the embryotoxic effects of ibuprofen on chick embryos using the CHEST test.
- To determine dose-dependent effects and potential teratogenicity.
Main Methods:
- Chick Embryotoxicity Screening Test (CHEST) was employed.
- Subgerminal and intraamniotic administration of ibuprofen at various doses and developmental stages.
- Observation of growth and developmental abnormalities.
Main Results:
- Doses of 0.03 mg of ibuprofen and higher caused caudal morphogenetic system (CMS) growth retardation.
- The direct embryotoxicity range was identified between 0.003 to 0.03 mg/embryo.
- Embryolethality and severe developmental defects (facial, cardiac, neural, limb) were rare, occurring mainly at the highest dose.
Conclusions:
- Ibuprofen exhibits dose-dependent embryotoxicity in chick embryos, primarily affecting caudal development.
- The study provides a basis for extrapolating potential risks in mammals, including humans.
- While severe malformations are infrequent, careful consideration of dosage during pregnancy is warranted.