[Therapy of dysseborrheic dermatitis with ketoconazole]

Thirty patients with dysseborrhoeic dermatitis (DD) of the scalp, 27 men and 3 women, were treated with 2% ketokonazole gel prepared in the Institute of Pharmacy of the M.M.A. Therapeutical effects was assessed on the basis of the objective clinical signs (erythema, desquamation) and subjective feeling of itching. Four weeks after the beginning of treatment the complete therapeutic response was obtained in 80% of patients (withdrawal of all clinical signs and subjective symptoms), good response was achieved in 16.6% and satisfying in 3.33% of patients. In no patients the preparation was without clinically evident effects. After cessation of the therapy, remission lasted from 2 to 12 weeks (mean, 4 weeks). The probable way of ketokonazole effect in DD is the inhibition of cytochrome P450 izoenzyme.