Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Carcinosarcoma of the prostate

G Y Lauwers¹, M Schevchuk, N Armenakas

¹Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.

The American Journal of Surgical Pathology

|April 1, 1993

Summary

Prostate carcinosarcoma, a rare biphasic tumor, can develop years after adenocarcinoma (ACA) treatment. Radiotherapy and hormonal therapy may contribute to its development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Oncologic outcomes of retroperitoneal lymph node dissection following first-line chemotherapy for metastatic non-seminomatous germ-cell tumors.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Same author

Reply by Authors.

The Journal of urology·2020

Same author

Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis.

Journal of internal medicine·2018

Same author

Reliability of histologic assessment in patients with eosinophilic oesophagitis.

Alimentary pharmacology & therapeutics·2018

Same author

Updated prostate imaging reporting and data system (PIRADS v2) recommendations for the detection of clinically significant prostate cancer using multiparametric MRI: critical evaluation using whole-mount pathology as standard of reference.

European radiology·2015

Same author

Standardised reporting protocol for endoscopic resection for Barrett oesophagus associated neoplasia: expert consensus recommendations.

Pathology·2014

Area of Science:

Oncology
Pathology

Background:

Prostate carcinosarcoma is a rare biphasic tumor comprising adenocarcinoma (ACA) and sarcomatous elements.
Only 12 cases have been previously reported in medical literature.

Observation:

Three new cases of prostate carcinosarcoma are presented, occurring 4-6 years post-initial ACA diagnosis.
Two patients underwent prostatectomy, pelvic radiotherapy, and hormonal therapy; one had pelvic lymphadenectomy and iodine-125 implants.
Histological analysis confirmed ACA with a later-appearing neoplastic mesenchymal component, including osteosarcomatous, chondrosarcomatous, and myosarcomatous differentiation in two cases.

Findings:

Two patients survived with metastatic disease at 9 and 17 months post-sarcoma diagnosis.
The third patient died from the disease 7 months after diagnosis.
Sarcomatoid transformation of ACA is the favored histogenesis, with radiotherapy and hormonal therapy potentially playing a role in tumorigenesis.

Implications:

This study expands the understanding of prostate carcinosarcoma, a rare and aggressive malignancy.
The findings suggest a potential link between prior treatments for prostate adenocarcinoma and the subsequent development of carcinosarcoma.
Further research is warranted to elucidate the exact mechanisms and identify potential therapeutic targets for this rare tumor.

Related Experiment Videos