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The relative effects of selective M1 muscarinic antagonists on rapid eye movement sleep
R K Zoltoski1, J Velazquez-Moctezuma, P J Shiromani
1Department of Psychiatry, Veterans Administration Medical Center, La Jolla, CA 92093.
Brain Research
|April 16, 1993
Abstract:
Three muscarinic antagonists, scopolamine, trihexyphenidyl and biperiden were systemically administered (0, 0.5, 1, 2 and 4 mg/kg) in rats. Scopolamine increased wakefulness and deceased sleep, both slow wave and REM. Trihexyphenidyl increased wakefulness and decreased REM sleep while biperiden decreased REM sleep selectively. The rank order REM-suppressing effect was roughly scopolamine and trihexyphenidyl having a greater suppressing effect than biperiden. These results suggest that the regulation of the sleep-wake cycle is at least partially controlled by the M1 muscarinic receptor.