Application of a programmable calculator in data fitting according to one and two compartment open models in clinical...

The plasma or blood concentration profiles are fitted by single or two compartment open models using log-linear regression analyses. For two compartment models, "feathering" is performed at 95% equilibration time obtained from raw pharmacokinetic data. The equations have been programmed onto a Texas Instrument SR 52 pocket calculator and recorded on 8.5 X 1.7 cm magnetic strips, facilitating drug dosage regimen calculations through individual patient titrations in a clinical setting.