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Gold therapy lowers serum interleukin 6 levels in rheumatoid arthritis
1Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, Scotland, UK.
The Journal of Rheumatology
|April 1, 1993
Abstract
Objective:
To determine the clinical utility and the effect of sodium aurothiomalate (GSTM) on serum interleukin 6 (IL-6) levels in patients with rheumatoid arthritis (RA).
Methods:
Open prospective study of 50 patients with RA treated with GSTM. Serum IL-6 measured by bioassay.
Results:
IL-6 showed correlations with Ritchie articular index, duration of morning stiffness and C-reactive protein. GSTM significantly reduced IL-6 levels.
Conclusions:
IL-6 is a potentially useful additional indicator of disease activity in RA and is modulated by GSTM.