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Plasma testosterone during pregnancy in the mouse

M S Barkley, S D Michael, I I Geschwind

    Endocrinology
    |May 1, 1977
    PubMed
    Summary

    Plasma testosterone (T) levels in mice show two distinct increases during pregnancy, with a significant rise around day 9 and another in late gestation. These hormonal shifts correlate with elevated estradiol levels near parturition.

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    Area of Science:

    • Reproductive biology
    • Endocrinology
    • Mammalian physiology

    Background:

    • Hormonal fluctuations during pregnancy are critical for successful gestation and parturition.
    • Testosterone (T) plays a role in mammalian reproductive processes, but its dynamic changes during pregnancy are not fully elucidated.
    • Understanding maternal hormonal profiles is essential for reproductive health research.

    Purpose of the Study:

    • To investigate the temporal patterns of plasma testosterone (T) levels throughout pregnancy in mice.
    • To identify specific phases of gestation associated with significant changes in T concentrations.
    • To correlate changes in T with estradiol levels during late pregnancy.

    Main Methods:

    • Longitudinal study design measuring plasma testosterone (T) levels.
    • Sampling conducted throughout pregnancy and on the day of parturition in selected mouse strains.
    • Hormone levels analyzed to determine concentration changes over gestational time.

    Main Results:

    • A pronounced surge in plasma testosterone (T) was observed during mid-pregnancy, peaking around day 9 in both studied strains.
    • A secondary elevation in plasma T was detected in the later stages of gestation (days 14-17).
    • This late-gestation increase in T coincided with elevated plasma estradiol levels.

    Conclusions:

    • Plasma testosterone (T) exhibits dynamic biphasic changes during mouse pregnancy.
    • These hormonal fluctuations, particularly the late-gestation rise in T alongside estradiol, may indicate roles in preparing for parturition.
    • Further research is warranted to explore the functional significance of these testosterone surges in pregnancy.

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