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Updated: Aug 17, 2026

Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells
Published on: May 9, 2011
Primary carcinoma of the fallopian tube
L Frigerio1, A Pirondini, M Pileri
1IIIa Clinica di Ostetricia e Ginecologia, Università degli Studi di Milano, Istituto Scientifico S. Raffaele, Italy.
Background:
Because of the rarity of fallopian tube cancer, clinical approaches have changed during the last 18 years.
Methods:
Twenty-nine patients with fallopian tube cancer were treated at the Gynecologic Oncology Department of Milan University from 1970 to 1988. The mean patient age was 59 years. Parity, symptomatology and histology were considered. Distribution by stage was as follows: I, 11 (37%); II, 10 (34%); III, 8 (27%) according to the Dodson classification. Twenty patients (69%) underwent surgery followed by pelvic irradiation. Adjuvant chemotherapy was performed in the treatment of 5 women with stage I disease, 6 with stage II, and all 8 with stage III.
Results:
Five-year overall survival was 41.38%: 47.6% at stages I and II, 25% at stage III. Radiotherapy has not been replaced by cisplatin-based multiagent chemotherapy. Optimal surgical debulking combined with accurate lymph node sampling are not followed by systematic use of repeat laparotomy.
Conclusions:
The procedures described in this work improve the clinical assessment and patient survival, and make different series comparable.
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