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A stable L-arginine-dependent relaxing factor released from cytotoxic-activated macrophages
H Uchizumi1, R Hattori, K Sase
1Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
The American Journal of Physiology
|May 1, 1993
Abstract:
It has been known that cytotoxic-activated macrophages release an unstable vasorelaxing substance, nitric oxide. We have found that a more stable relaxing factor is released from those cells. This factor seems to be synthesized from L-arginine. It acts through the activation of soluble guanylate cyclase without affecting membrane potential. It has little charge at nearly neutral pH, and its molecular weight is < 500.