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Related Experiment Videos

Defecatory function in Parkinson's disease: response to apomorphine

L L Edwards1, E M Quigley, R K Harned

  • 1Section of Neurology, University of Nebraska Medical Center, Omaha 68198-2045.

Annals of Neurology
|May 1, 1993
PubMed
Summary

Apomorphine, a dopamine agent, improved bowel dysfunction and anorectal function in Parkinson's disease (PD) patients. This suggests dopamine deficiency contributes to these issues in PD, offering potential therapeutic avenues.

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Area of Science:

  • Neurology
  • Gastroenterology
  • Pharmacology

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder affecting dopamine-producing neurons.
  • Anorectal dysfunction, including defecation problems, is a common non-motor symptom in PD patients.
  • The underlying mechanisms of PD-related anorectal dysfunction are not fully understood.

Purpose of the Study:

  • To investigate the effects of the dopaminergic agent apomorphine on defecation and anorectal function in patients with Parkinson's disease.
  • To assess whether apomorphine can ameliorate observed abnormalities in gastrointestinal and anorectal functions.

Main Methods:

  • The study included 8 subjects diagnosed with Parkinson's disease.
  • Evaluations comprised a gastrointestinal symptom survey, extrapyramidal assessment, defecating proctogram, and anorectal manometry.

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  • Abnormal baseline studies were repeated after administering apomorphine.

    • Main Results:

    • Apomorphine administration led to normalization of defecographic abnormalities in 1 out of 3 subjects.
    • Significant improvements in anorectal manometric parameters were observed in all 5 subjects who underwent repeat manometry.
    • Apomorphine demonstrated a positive impact on both defecation and anorectal manometric measures.

    Conclusions:

    • Apomorphine can effectively correct anorectal dysfunction observed in Parkinson's disease patients.
    • Anorectal abnormalities in PD may stem from dopamine deficiency associated with the disease process.
    • These findings suggest potential therapeutic applications of apomorphine for managing gastrointestinal symptoms in Parkinson's disease.