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[Helicobacter pylori infection and duodeno-gastric reflux]
J M Angulo1, J Arana, P Zubillaga
1Servicio de Cirugía Pediátrica, Hospital Ntra. Sra. de Aránzazu, San Sebastián.
Insights
Duodenogastric reflux and Helicobacter pylori (HP) are frequently diagnosed together in children experiencing chronic abdominal pain. Studies show significant differences in reflux parameters in these children compared to healthy controls.
Area of Science:
- Pediatric Gastroenterology
- Gastrointestinal Motility Disorders
- Microbiology
Background:
- Chronic abdominal pain is a common complaint in children.
- Helicobacter pylori (HP) infection is a known factor in gastrointestinal issues.
- Duodenogastric reflux (DGR) involves the abnormal backflow of duodenal contents into the stomach.
Purpose of the Study:
- To investigate the prevalence and characteristics of duodenogastric reflux in children with chronic abdominal pain and HP infection.
- To compare DGR parameters between children with HP and chronic abdominal pain versus a healthy control group.
Main Methods:
- Utilized 24-hour gastric pH-metry to measure DGR parameters.
- Evaluated 11 children with chronic abdominal pain and HP.
- Compared findings with a control group of 40 healthy children.
Main Results:
- Children with DGR and HP showed significantly higher numbers of reflux episodes (NR: 92.87 ± 27.66).
- Significantly more prolonged reflux episodes (NR > 5M: 11.45 ± 4.68) and longer reflux durations (LR: 67.37 ± 45.57) were observed.
- A significantly larger alkaline reflux area (AA: 604.89 ± 443.54) was detected in the patient group.
Conclusions:
- Duodenogastric reflux and Helicobacter pylori infection frequently coexist in children with chronic abdominal pain.
- These findings suggest a potential link between DGR, HP infection, and pediatric chronic abdominal pain.
Abstract:
We have studied and measured the duodenogastric reflux in 11 children with chronic abdominal pain and Helicobacter pylori (HP) through 24-hours gastric pH-metric studies. All parameters evaluated: Number of reflux episodes (NR 92.87 +/- 27.66), number of reflux episodes longer than 5.0 minutes (NR > 5M 11.45 +/- 4.68), longest reflux episode (LR 67.37 +/- 45.57) and alkaline reflux area (AA 604.89 +/- 443.54) had significative differences against a normal group (40 children). We concluded that duodenogastric reflux and HP are frequent together.