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[Immune tolerance in Masugi nephritis]
1St. Josef-Hospital, Universitätskinderklinik Bochum, Deutschland.
Induction of immunotolerance was studied in the autologous phase of experimental rabbit glomerulonephritis. The glomerulonephritis was induced by intravenous injection of duck anti-rabbit glomerular basement membrane globulin into rabbits. One single intravenous injection of that nephrotoxis immunoglobulin (20 mg/kg body weight) into rabbits was followed by glomerulonephritis with glomerular hypercellularity and proteinuria. Another group of rabbits was pretreated on their first day of age, using 1.5 mg/animal of immunoglobulin from duck. Nephritis did not grow manifest when the animals received another injection (20 mg/kg body weight), after eight weeks. Passive (intracutaneous) Arthus reaction (triggered by duck immunoglobulin) was recordable with equal intensity from either group.
Induction of immunotolerance was studied in the autologous phase of experimental rabbit glomerulonephritis. The glomerulonephritis was induced by intravenous injection of duck anti-rabbit glomerular basement membrane globulin into rabbits. One single intravenous injection of that nephrotoxis immunoglobulin (20 mg/kg body weight) into rabbits was followed by glomerulonephritis with glomerular hypercellularity and proteinuria. Another group of rabbits was pretreated on their first day of age, using 1.5 mg/animal of immunoglobulin from duck. Nephritis did not grow manifest when the animals received another injection (20 mg/kg body weight), after eight weeks. Passive (intracutaneous) Arthus reaction (triggered by duck immunoglobulin) was recordable with equal intensity from either group.