Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oral versus transdermal hormone replacement therapy

J C Stevenson1, D Crook, I F Godsland

  • 1Wynn Institute for Metabolic Research, London, U.K.

International Journal of Fertility and Menopausal Studies
|January 1, 1993
PubMed
Summary

Transdermal hormone replacement therapy (HRT) effectively prevents bone loss and improves cardiovascular risk markers in postmenopausal women. It offers metabolic benefits over oral HRT, particularly for glucose metabolism and triglyceride levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COVID-19 pandemic impact on adolescent mental health: a reassessment accounting for development.

European child & adolescent psychiatry·2024
Same author

Lower respiratory tract infection in the community: associations between viral aetiology and illness course.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020
Same author

Randomized controlled trials define shape of dose response for Pollinex Quattro Birch allergoid immunotherapy.

Allergy·2018
Same author

Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018
Same author

Comparison of resistive heating and forced-air warming to prevent inadvertent perioperative hypothermia.

British journal of anaesthesia·2016
Same author

The effects of a resistive warming mattress during caesarean section: a randomised, controlled trial.

International journal of obstetric anesthesia·2014

Area of Science:

  • Endocrinology
  • Metabolic Medicine
  • Bone Biology

Background:

  • Menopause leads to ovarian function loss, increasing risks for cardiovascular disease and osteoporosis.
  • Hormone replacement therapy (HRT) can mitigate these postmenopausal health risks.
  • Oral HRT poses risks due to high hepatic exposure, unlike transdermal administration.

Purpose of the Study:

  • To compare the metabolic effects of transdermal HRT versus oral HRT in healthy postmenopausal women.
  • To evaluate HRT's impact on bone density, lipids, lipoproteins, and glucose/insulin kinetics.
  • To assess cardiovascular disease risk markers associated with different HRT administration routes.

Main Methods:

  • A 3-year study involving 96 healthy postmenopausal women.

Related Experiment Videos

  • Comparison of continuous oral conjugated estrogens/dl-norgestrel with continuous transdermal estradiol-17 beta/norethindrone acetate.
  • Measurements included bone biochemistry/density, serum lipids/lipoproteins/apolipoproteins, and glucose/insulin/C-peptide concentrations.

    • Main Results:

    • Both oral and transdermal HRT regimens prevented bone loss and favorably altered lipid profiles.
    • Transdermal estrogen lowered triglycerides; oral estrogen increased them.
    • Oral HRT worsened glucose tolerance and increased insulin secretion, unlike transdermal HRT.

    Conclusions:

    • Transdermal HRT is as effective as oral HRT for preventing postmenopausal osteoporosis.
    • Transdermal HRT demonstrates superior or equivalent metabolic profiles compared to oral HRT, especially regarding cardiovascular risk markers.
    • Transdermal HRT offers a potentially safer alternative for managing menopausal symptoms and associated health risks.