Sodium valproate: quantitative EEG and serum levels in volunteers and epileptics

Twelve healthy adults and 12 epileptics had quantitative EEG tests while taking valproic acid. The results indicated that the total power of dominant frequency band and the frequency of dominant occipital rhythm were relatively stable in healthy awake adults. A single 400 mg oral dose of sodium valproate had similar influence on the total power of dominant frequency band in both healthy adults and epileptics. The total power of dominant frequency band tended to rise at 2 and 6 hours after medication in subjects with serum VPA concentrations reaching a peak after 2 hours. There was a tendency to rise at 4 and 8 hours in subjects with serum VPA concentrations which peaked after 4 hours. The curve of the total power with time had two peaks. A single oral dose of sodium valproate did not have a marked influence on the frequency of dominant rhythm in the occipital areas in healthy adults or in epileptics.