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The development of synaptic function and integration in the central auditory system

D H Sanes1

  • 1Center for Neural Science, New York University, New York 10003.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|June 1, 1993
PubMed
Summary
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Synaptic transmission in the gerbil lateral superior olive (LSO) matures rapidly post-birth. Early development shows prolonged postsynaptic potentials (PSPs) and afferent elimination, impacting auditory processing.

Area of Science:

  • Neuroscience
  • Auditory System Development

Background:

  • Assessing inhibitory synaptic transmission is challenging due to difficulties in stimulating intrinsic neurons independently.
  • The gerbil lateral superior olive (LSO) offers a unique model for studying synaptic maturation due to physically distinct afferent projections.

Purpose of the Study:

  • To compare the postnatal maturation of excitatory and inhibitory synaptic function in the gerbil LSO.
  • To investigate the developmental changes in synaptic properties and their impact on auditory processing.

Main Methods:

  • Intracellular recordings in brain slice preparations.
  • Electrical stimulation of discrete afferent projections.
  • Analysis of postsynaptic potentials (PSPs), including excitatory (EPSPs) and inhibitory (IPSPs).

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Main Results:

  • Synaptic transmission was prominent at birth, with significantly longer EPSPs and IPSPs compared to mature animals.
  • Temporal summation of PSPs occurred in neonates, leading to prolonged depolarizations/hyperpolarizations.
  • A significant decrease in the number of afferents and IPSP duration was observed during the first three postnatal weeks.

Conclusions:

  • Immature synaptic properties in the LSO, including compromised amplitude and temporal processing, likely compound cochlear and cochlear nucleus inadequacies.
  • Spontaneous afferent discharge may significantly influence LSO development even before auditory sound responses.
  • The rapid maturation of synaptic function is crucial for developing auditory processing capabilities.