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Related Experiment Videos

Unexplained infertility

R A Lobo1

  • 1Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.

The Journal of Reproductive Medicine
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Unexplained infertility requires thorough investigation. Empiric treatments like superovulation with intrauterine insemination are common, with in vitro fertilization (IVF) as a preferred option when fertilization failure is suspected.

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Area of Science:

  • Reproductive Medicine
  • Obstetrics & Gynecology

Background:

  • Unexplained infertility (UI) is diagnosed after standard infertility investigations yield normal results.
  • UI diagnosis can be arbitrary, as specific causes may still exist despite negative basic tests.
  • Spontaneous pregnancy rates in UI couples are around 60% within three years.

Purpose of the Study:

  • To outline diagnostic and therapeutic strategies for unexplained infertility.
  • To discuss the role of further investigations and empiric treatments.
  • To highlight the importance of in vitro fertilization (IVF) in specific cases.

Main Methods:

  • Review of diagnostic criteria and standard infertility workup.
  • Description of empiric treatment protocols, including superovulation with intrauterine insemination (IUI).

Related Experiment Videos

  • Discussion of alternative and advanced reproductive technologies like IVF.

    • Main Results:

    • Empiric superovulation with IUI is a common treatment, with expected cycle fecundity influenced by female age.
    • Cycle fecundity decreases significantly after age 40.
    • Fertilization failure is a recognized cause of UI, supporting IVF.

    Conclusions:

    • Further testing beyond basic infertility evaluations is warranted in UI cases.
    • Empiric therapy, particularly superovulation with IUI, is a standard approach.
    • In vitro fertilization (IVF) is recommended when fertilization failure is suspected or after failed empiric treatments.