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Related Experiment Videos

Recurrent abortion

D R Mishell1

  • 1Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.

The Journal of Reproductive Medicine
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Recurrent spontaneous abortion (RSA) affects 0.5% of women, with causes including fetal genetics and maternal uterine issues. Immunologic factors and lupus anticoagulant activity remain controversial etiologies for RSA.

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • Immunology

Background:

  • Recurrent spontaneous abortion (RSA) impacts approximately 0.5% of women.
  • Etiologies are broadly categorized into fetal (genetic/chromosomal abnormalities) and maternal (uterine abnormalities).
  • The role of immunologic factors and lupus anticoagulant activity in RSA is debated.

Purpose of the Study:

  • To review the established and controversial causes of recurrent spontaneous abortion.
  • To evaluate the efficacy and necessity of specific diagnostic and therapeutic interventions.

Main Methods:

  • Literature review of fetal and maternal causes of recurrent abortion.
  • Analysis of evidence regarding immunologic factors, lupus anticoagulant, and anticardiolipin antibodies.

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  • Assessment of the cost-effectiveness and necessity of histocompatibility locus antigen typing and immunotherapy.

    • Main Results:

    • Fetal genetic/chromosomal abnormalities and maternal uterine abnormalities are primary causes of RSA.
    • Histocompatibility locus antigen typing and immunotherapy are not cost-effective or necessary for couples with RSA.
    • Treatment for lupus anticoagulant or anticardiolipin antibodies shows no superiority over no treatment and is considered investigational.

    Conclusions:

    • Established fetal and maternal factors are key to understanding recurrent spontaneous abortion.
    • Current evidence does not support the routine use of histocompatibility locus antigen typing or immunotherapy.
    • Investigational treatments for antiphospholipid antibodies in RSA require further research.