Tentativeness and fervor in cell biology require negative and positive feedforward control

End-product feedback regulates early steps in metabolic pathways, affecting activation and the rate of end-product synthesis. Early formation of end-product also modifies later steps in the synthesis of end-product. We designate this form of regulation feedforward. Negative feedback/feedforward by end-products may result in homeostasis, but also in physiologic tentativeness. Positive feedback/feedforward by end-product gives rise to fervid events. Tentativeness and fervor, due to negative and positive feedforward rather than feedback, explain otherwise puzzling aspects of immunology and endocrinology.