Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic refractory headache

N T Mathew1

  • 1Houston Headache Clinic, TX 77004.

Neurology
|June 1, 1993
PubMed
Summary
This summary is machine-generated.

Chronic daily headache affects 40% of clinic patients, often stemming from transformed migraine. Overuse of pain medications like analgesics and ergotamine frequently leads to medication-induced or rebound headaches in these individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Randomized, placebo-controlled trial of propranolol added to topiramate in chronic migraine.

Neurology·2012
Same author

Zolmitriptan nasal spray in the acute treatment of cluster headache: a double-blind study.

Neurology·2007
Same author

Review of clinical trials using early acute intervention with oral triptans for migraine management.

International journal of clinical practice·2006
Same author

Naratriptan: a review.

Expert opinion on investigational drugs·2005
Same author

Pathophysiology, epidemiology, and impact of migraine.

Clinical cornerstone·2003
Same author

Intranasal sumatriptan in cluster headache: randomized placebo-controlled double-blind study.

Neurology·2003
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Area of Science:

  • Neurology
  • Clinical Medicine

Background:

  • Chronic daily headache (CDH) is a significant condition affecting a large proportion of patients in specialized headache clinics.
  • Understanding the subtypes and contributing factors of CDH is crucial for effective patient management.

Purpose of the Study:

  • To investigate the prevalence of different CDH subtypes in a clinical setting.
  • To determine the rate of symptomatic medication overuse among CDH patients.
  • To identify the common types of medication overuse leading to drug-induced or rebound headaches.

Main Methods:

  • Retrospective analysis of 630 patients diagnosed with chronic daily headache.
  • Classification of patients into transformed migraine, chronic tension-type headache, and new daily persistent headache categories.

Related Experiment Videos

  • Assessment of medication overuse patterns, focusing on analgesics and ergotamine.

    • Main Results:

    • Approximately 40% of patients in major headache clinics present with chronic daily headache.
    • Transformed migraine was the most common diagnosis (489 patients), followed by chronic tension-type headache (84 patients) and new daily persistent headache (57 patients).
    • A high percentage (73%) of these patients were found to overuse symptomatic medications, commonly analgesics and ergotamine, resulting in medication-induced or rebound headaches.

    Conclusions:

    • Transformed migraine is the predominant subtype of chronic daily headache in clinical populations.
    • Symptomatic medication overuse is highly prevalent in patients with chronic daily headache.
    • Drug-induced headache and rebound headache are common consequences of medication overuse in this patient group, highlighting the need for careful medication management strategies.