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Fetal circulatory endothelin-1,2 in the midtrimester
E Schiff1, Y Zalel, S A Friedman
1Department of Obstetrics and Gynecology, Tel-Aviv University, Israel.
Gynecologic and Obstetric Investigation
|January 1, 1993
Summary
This study detected endothelin-1,2 in fetal umbilical-vein blood, suggesting its role in regulating fetal circulation during pregnancy. These findings offer insights into prenatal hemodynamic regulation.
Area of Science:
- Perinatology
- Cardiovascular Physiology
- Endocrinology
Background:
- Endothelin-1,2 is a potent vasoconstrictor peptide.
- Its role in fetal circulation is not well-defined.
Purpose of the Study:
- To measure endothelin-1,2 levels in fetal umbilical-vein blood.
- To explore the potential role of endothelin in fetal hemodynamics.
Main Methods:
- Umbilical-vein blood samples were collected from 8 fetuses (19-22 weeks gestation) undergoing cordocentesis.
- Radioimmunoassay was used to quantify immunoreactive endothelin-1,2 levels.
Main Results:
- Endothelin-1,2 was detected in 7 out of 8 fetuses.
- Concentrations ranged from 8.5 to 19.2 fmol/ml, with a mean of 13.4 fmol/ml.
Conclusions:
- Endothelin-1,2 is present in the fetoplacental circulation.
- Endothelin may play a role in regulating fetal hemodynamics in utero.