Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A method for sleep depriving rats

S J Stefurak, M L Stefurak, W B Mendelson

    Pharmacology, Biochemistry, and Behavior
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Functional brain imaging, sleep, and sleep deprivation: contributions to the "overarousal" hypothesis of depression.

    Acta neuropsychiatrica·2016
    Same author

    An open-label, 12-week clinical and sleep EEG study of nefazodone in chronic combat-related posttraumatic stress disorder.

    The Journal of clinical psychiatry·2002
    Same author

    Recent advances in sleep and chronobiology.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2001
    Same author

    Sleep deprivation as a model experimental antidepressant treatment: findings from functional brain imaging.

    Depression and anxiety·2001
    Same author

    Sleep abnormalities during abstinence in alcohol-dependent patients. Aetiology and management.

    CNS drugs·2001
    Same author

    Increased cerebral response during a divided attention task following sleep deprivation.

    Journal of sleep research·2001
    Same journal

    Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

    Pharmacology, biochemistry, and behavior·2026
    See all related articles

    A novel method effectively sleep-deprived rats using rotating cylinders. Electroencephalogram (EEG) data revealed a significant reduction in total sleep time without affecting REM or non-REM sleep stages.

    Area of Science:

    • Neuroscience
    • Sleep Science

    Background:

    • Sleep deprivation is a critical factor in neurological research.
    • Understanding sleep patterns in rodents is essential for translational studies.
    • Previous methods lacked detailed electrophysiological data.

    Purpose of the Study:

    • To introduce a new method for sleep deprivation in rats.
    • To analyze the impact of this method on sleep architecture using EEG.
    • To quantify changes in total sleep, REM, and non-REM sleep.

    Main Methods:

    • Sleep deprivation of up to 12 rats concurrently.
    • Utilized large rotating cylinders for the procedure.
    • Acquired electroencephalogram (EEG) data during sleep deprivation.

    Related Experiment Videos

    Main Results:

    • Total sleep time significantly reduced from 47.0% to 3.8% over a 24-hour period.
    • EEG data confirmed the efficacy of the sleep deprivation technique.
    • No selective reduction observed in Rapid Eye Movement (REM) or non-REM sleep.

    Conclusions:

    • The rotating cylinder method is highly effective for inducing sleep deprivation in rats.
    • This technique allows for detailed electrophysiological monitoring.
    • The method impacts overall sleep duration without altering specific sleep stages.