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Related Experiment Videos

Complement factor I deficiency with recurrent aseptic meningitis

A J Bonnin1, H J Zeitz, A Gewurz

  • 1Department of Immunology/Microbiology, Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill.

Archives of Internal Medicine
|June 14, 1993
PubMed
Summary
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Total deficiency of factor I, a complement protein, can lead to recurrent aseptic meningitis, not just bacterial infections. This finding expands understanding of factor I

Area of Science:

  • Immunology
  • Infectious Diseases

Background:

  • Factor I deficiency typically causes pyogenic bacterial infections.
  • The complement system is crucial for immune defense.

Observation:

  • A patient with total factor I deficiency presented with nine episodes of aseptic meningitis over two years.
  • No history of bacterial sepsis was noted, and meningitis recurred despite antibiotic prophylaxis.

Findings:

  • Serum complement levels were low for C3, factor B, and factor H, with undetectable factor I.
  • The patient had a minimally elevated antinuclear antibody titer but no other immune defects.

Implications:

  • Factor I deficiency may predispose individuals to aseptic meningitis.
  • This expands the known clinical spectrum of complement deficiencies.

Related Experiment Videos

  • Highlights the role of complement in non-bacterial meningitis pathogenesis.