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Pathogenesis and animal studies of Parkinson's disease
1Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University, München, Germany.
Current Opinion in Neurology and Neurosurgery
|June 1, 1993
Abstract:
This article reviews the past year's literature on pathogenesis and animal studies of Parkinson's disease. Studies on aging, genetic aspects, environmental factors, melanin, altered iron metabolism, oxidative stress, defective mitochondrial respiration, excitatory amino acids, and trophic support are reviewed in relation to the vulnerability of dopaminergic nigral neurons and the pathogenesis of Parkinson's disease.