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[The treatment of metastasized kidney cancer. Current data and perspectives]
F Desgrandchamps1, O Cussenot, J M Maréchal
1Service d'Urologie, Hôpital Saint-Louis, Paris.
Abstract:
Metastatic renal cancer has a poor prognosis because of the limited impact of traditional treatment modalities on this tumour. The few long-term survivals obtained after isolated surgical resection of the primary tumour or its metastases can be attributed to the occasionally unpredictable natural history of this tumour and isolated surgical resection generally does not appear to improve the survival of these patients. Among non-surgical treatments, radiotherapy is purely palliative and hormone therapy has been shown to be ineffective. New therapeutic approaches have been recently developed, suggesting a possible improvement in the prognosis of metastatic renal cancer. A better understanding of the mechanisms of chemoresistance of renal cancer should lead, in the near future, to the use of drugs capable of increasing the efficacy of cytotoxic chemotherapy in this tumour. The results obtained with new forms of immunotherapy open up prospects for combined immunosurgical modalities.
Insights
Metastatic renal cancer has a poor prognosis. New treatments like immunotherapy and improved chemotherapy offer hope for better outcomes in advanced kidney cancer.
Area of Science:
- Oncology
- Nephrology
Context:
- Metastatic renal cancer presents significant challenges due to limited efficacy of traditional treatments.
- Current therapeutic options, including surgery, radiotherapy, and hormone therapy, offer minimal long-term survival benefits.
Purpose:
- To review the current landscape of metastatic renal cancer treatment.
- To highlight emerging therapeutic strategies and their potential impact on patient prognosis.
Summary:
- Traditional treatments for metastatic renal cancer have shown limited success.
- Advances in understanding chemoresistance are paving the way for more effective chemotherapy.
- Novel immunotherapies are showing promise, particularly in combination with surgical approaches.
Impact:
- Improved understanding of chemoresistance mechanisms may enhance cytotoxic chemotherapy efficacy.
- Emerging immunotherapies and combined modalities suggest a potential improvement in the prognosis of metastatic renal cancer.