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Updated: Aug 7, 2026

Analytical Techniques for Assaying Nitric Oxide Bioactivity
Published on: June 18, 2012
Nitrate tolerance--mechanisms and prevention
1Hartford Hospital, University of Connecticut, School of Pharmacy, Storrs.
Abstract:
Nitrate tolerance is of significant clinical concern and every effort should be made to avoid this undesirable effect. The mechanism of tolerance is not clear but probably is multifactorial. Although ACE inhibitors, diuretics, and NAC have been tried as preventative measures, the only method proven to maintain nitrate effectiveness in patients is a nitrate-free interval. The results of further studies designed to determine the actual period of time that the patient is protected will be helpful. This may guide us in choosing the optimal nitrate therapy.
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