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Effect of in vitro acyclovir treatment on selected functions of blood-derived macrophages
A M Stenseth1, H Rollag, M Degré
1Institute of Bacteriology, Rikshospitalet, University of Oslo, Norway.
Chemotherapy
|May 1, 1993
Abstract:
The effect of acyclovir (ACV) treatment on selected functions of human blood-derived macrophages was examined. ACV was not cytotoxic when applied in a wide range of concentrations. Only minor effects on macrophage functions were observed when cells were treated with therapeutic concentrations of ACV:phagocytosis and the production of interferon and tumor necrosis factor were slightly enhanced, while the production of lysozyme was reduced, in a dose-dependent manner. Interferon production was also reduced in the presence of high concentrations of ACV.