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Migrating myoelectric complex and jejunal slow-wave propagation after Roux gastrectomy in dogs
A Woodward1, L F Sillin, A Bortoff
1Department of Surgery, VAMC, Syracuse, New York.
Digestive Diseases and Sciences
|June 1, 1993
Summary
Roux-en-Y gastrectomy can cause gastric stasis due to abnormal backward electrical signals in the jejunum. This study found these retrograde waves occur even during normal digestive cycles, potentially explaining Roux Y stasis syndrome.
Area of Science:
- Gastroenterology
- Surgical Physiology
- Electrophysiology
Background:
- Roux-en-Y gastrectomy is frequently linked to gastric stasis.
- Retrograde electrical activity in the jejunum is a suspected cause of Roux Y stasis syndrome.
Purpose of the Study:
- To investigate the occurrence and extent of retrograde slow-wave propagation in the jejunum after Roux-en-Y gastrectomy.
- To determine if retrograde propagation persists during the fasted state, specifically during phase III of the migrating myoelectric complex.
Main Methods:
- Six dogs underwent Roux-en-Y gastrectomy with bipolar electrodes implanted along the Roux limb.
- Four control dogs with electrodes were used for comparison.
- Migrating myoelectric complexes were recorded and analyzed for retrograde slow-wave propagation.
Main Results:
- In Roux gastrectomy dogs, retrograde slow-wave propagation was observed during all phases of the migrating myoelectric complex (Phase I: 56%, Phase II: 60%, Phase III: 58%).
- Control dogs showed minimal retrograde propagation (0-1%).
- The incidence of retrograde propagation in Roux dogs was significantly higher than in controls (P < 0.006).
Conclusions:
- Retrograde propagation of jejunal electrical slow waves and spike bursts occurs in dogs after Roux-en-Y gastrectomy, even during phase III.
- This abnormal electrical activity in the Roux limb may be a significant contributing factor to the development of Roux Y stasis syndrome.