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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

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Related Experiment Video

Updated: Jul 21, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Blistering distal dactylitis caused by Staphylococcus aureus

M C Norcross1, D F Mitchell

  • 1Department of Family Practice, Naval Hospital, Charleston, South Carolina.

Cutis
|May 1, 1993
PubMed
Summary

Blistering distal dactylitis, typically affecting one finger, can be caused by Staphylococcus aureus. This case involved multiple fingers and responded well to Augmentin, suggesting a potential diagnostic clue.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Dermatology

Background:

  • Blistering distal dactylitis (BDD) is a superficial bacterial infection.
  • It commonly affects the volar aspect of a single digit's distal phalanx.
  • Group A beta-hemolytic streptococci are the usual causative agents.

Observation:

  • A pediatric case of BDD presented with unusual involvement of all fingers and thumbs.
  • The causative agent identified was Staphylococcus aureus, differing from the typical Streptococcus etiology.
  • Diagnosis was confirmed via Gram's stain and bacterial culture.

Findings:

  • Staphylococcus aureus can cause blistering distal dactylitis.
  • Widespread digital involvement in BDD may indicate S. aureus infection.

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Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
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Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

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A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
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A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

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Last Updated: Jul 21, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

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A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
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A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

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  • Prompt diagnosis and targeted antibiotic therapy are crucial for effective treatment.

    • Implications:

    • This case expands the known spectrum of pathogens causing BDD.
    • Clinicians should consider S. aureus in cases of BDD affecting multiple digits.
    • Early identification of the causative agent guides appropriate antimicrobial selection and improves patient outcomes.