CD45 expression by murine B cells and T cells: alteration of CD45 isoforms in subpopulations of activated B cells
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K S Hathcock1, H Hirano, R J Hodes
1Experimental Immunology Branch National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Immunologic Research
|January 1, 1993
Abstract:
The CD45 family of high molecular weight cell surface glycoproteins is abundantly expressed by virtually all hematopoietic cells. CD45 molecules exist as multiple isoforms whose extracellular portions vary in protein structure and carbohydrate content but whose intracellular portions are highly conserved and possess tyrosine phosphatase activity. In this review we summarize current studies describing CD45 isoform expression on peripheral and thymic lymphocytes. Further, we analyze changes in CD45 isoform expression by selective populations of activated B cells.