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[Cutaneous candidiasis due to Candida parapsilosis occurring in the course of idiopathic aplastic anemia]
M C Machet1, E Diot, E Stéphanov
1Service d'Anatomie Pathologique, CHU Trousseau, Tours.
Abstract:
Candida parapsilosis is a very common and saprophytic fungus. Its pathogenic role has been reported in intensive care units after invasive instrumentations. We report a case of dermal candidiasis due to Candida parapsilosis occurring in an immunocompromised patient suffering from aplastic anemia treated with corticosteroids. The histopathological aspect was non specific, showing a polymorphous granulomatous reaction in the middermis. Findings of periodic acid-Schiff and Grocott-Gomori stains revealed a large number of pseudohyphae and spores. Candida parasilosis was cultured from a skin biopsy. The route of skin infection is discussed: direct inoculation or septic localization after fungemia.
Insights
A rare case of skin infection by Candida parapsilosis occurred in an immunocompromised patient with aplastic anemia. This study highlights potential routes of dermal candidiasis in susceptible individuals.
Area of Science:
- Mycology
- Dermatology
- Infectious Diseases
Background:
- Candida parapsilosis is a common fungus with a known pathogenic role in healthcare settings.
- Invasive procedures can increase the risk of Candida infections, particularly in intensive care units.
Observation:
- A case of dermal candidiasis caused by Candida parapsilosis is presented.
- The affected patient was immunocompromised, suffering from aplastic anemia and undergoing corticosteroid treatment.
Findings:
- Histopathology revealed a non-specific polymorphous granulomatous reaction in the dermis.
- Periodic acid-Schiff and Grocott-Gomori stains identified numerous pseudohyphae and spores.
- Candida parapsilosis was successfully cultured from a skin biopsy specimen.
Implications:
- This case underscores the importance of considering Candida infections in immunocompromised patients with skin lesions.
- The study discusses potential infection routes, including direct inoculation and hematogenous spread (fungemia).
- Further research may elucidate specific risk factors and optimal management strategies for dermal candidiasis in this population.