Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scleroderma and fasciitis in children

C M Black1

  • 1Royal Free Hospital, London, UK.

Current Opinion in Rheumatology
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Childhood scleroderma primarily affects localized skin and soft tissues, differing from adult forms. Juvenile eosinophilic fasciitis is rare, with unclear causes and overlapping symptoms with other scleroderma types.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rationale and recommendations for improving early-stage oncology diagnosis, treatment, and access.

Journal of medical economics·2026
Same author

Health-related quality of life outcomes from KEYNOTE-412: chemoradiotherapy with or without pembrolizumab in participants with head and neck squamous cell carcinoma.

Frontiers in oncology·2025
Same author

In vitro effects of macrophages on orthopaedic implant alloys and local release of metallic alloy components.

The bone & joint journal·2020
Same author

Small Talk: Identifying communication problems in maltreated children.

Child abuse & neglect·2017
Same author

A randomized trial comparing balloon kyphoplasty and vertebroplasty for vertebral compression fractures due to osteoporosis.

AJNR. American journal of neuroradiology·2014
Same author

Multisociety Consensus Quality Improvement Guidelines for Intra-Arterial Catheter-Directed Treatment of Acute Ischemic Stroke: implications for neuroradiology and stroke centers.

AJNR. American journal of neuroradiology·2013
Same journal

New approaches to the management of cutaneous lupus.

Current opinion in rheumatology·2026
Same journal

"Updates in chronic nonbacterial osteomyelitis: emerging insights across the age spectrum".

Current opinion in rheumatology·2026
Same journal

Difficult-to-treat, complex-to-manage, treatment-refractory spondyloarthritis: semantics or substance?

Current opinion in rheumatology·2026
Same journal

Update on IgA nephropathy: implications for treatment in IgA vasculitis: a guide for rheumatologists.

Current opinion in rheumatology·2026
Same journal

Polyarticular juvenile idiopathic arthritis: insights from genetic studies on disease risk and pathogenesis.

Current opinion in rheumatology·2026
Same journal

Immune dysregulation in children with Down syndrome: clinical implications and emerging therapies.

Current opinion in rheumatology·2026
See all related articles

Area of Science:

  • Pediatric Rheumatology
  • Dermatology
  • Immunology

Background:

  • Scleroderma encompasses a range of disorders that can manifest in childhood.
  • Childhood scleroderma predominantly presents as localized disease affecting skin and soft tissues, unlike the more common generalized forms in adults.
  • Juvenile-onset eosinophilic fasciitis is a rare condition with limited existing literature.

Purpose of the Study:

  • To review the clinical presentation of scleroderma in children.
  • To explore the etiologic, immunologic, and pathogenic factors contributing to juvenile-onset scleroderma.
  • To discuss the similarities and overlaps between childhood eosinophilic fasciitis, morphea, and linear scleroderma.

Main Methods:

  • Literature review of childhood scleroderma, focusing on eosinophilic fasciitis.

Related Experiment Videos

  • Analysis of clinical patterns in juvenile-onset scleroderma.
  • Discussion of potential multifactorial etiopathogenesis.

    • Main Results:

    • Localized scleroderma is more common in children than generalized forms.
    • Childhood eosinophilic fasciitis shares similarities with adult presentations, including blurred diagnostic lines with morphea and linear scleroderma.
    • The etiopathogenesis of juvenile scleroderma is largely unknown and likely multifactorial.

    Conclusions:

    • Childhood scleroderma exhibits distinct patterns compared to adult disease, with localized manifestations being predominant.
    • Further research is needed to elucidate the complex etiopathogenesis of juvenile-onset scleroderma.
    • The heterogeneity suggests juvenile scleroderma may comprise multiple distinct disease entities.