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NERDS syndrome: an additional case report
P Zenarola1, L Melillo, M Bisceglia
1Department of Dermatology, Casa Sollievo della Sofferenza' Hospital, IRCCS, S. Giovanni Rotondo, Italy.
Dermatology (Basel, Switzerland)
|January 1, 1995
Summary
This study details a rare eosinophilic disorder, NERDS (nodules, eosinophilia, rheumatism, dermatitis, swelling), presenting a third case. Findings highlight key clinical features and cellular changes in this unique condition.
Area of Science:
- Rheumatology
- Dermatology
- Immunology
Background:
- NERDS (nodules, eosinophilia, rheumatism, dermatitis, swelling) is a recently described eosinophilic disorder.
- Understanding the clinical spectrum and cellular basis of NERDS is crucial for diagnosis and management.
Observation:
- This report presents the third documented case of NERDS.
- The patient exhibited joint and skin issues, nodules, xerosis, and recurrent urticaria with angioedema.
- Drug-induced rash and lymphadenopathy were noted, alongside persistent leukocytosis with high eosinophil counts.
Findings:
- Eosinophils in this case predominantly showed a hypodense phenotype, indicating activation.
- Flow cytometry revealed a proliferation of activated CD4+/OKDR+ T helper cells and CD25+/OKDR+ eosinophils during the acute phase.
Implications:
- This case expands the understanding of NERDS' clinical presentation.
- Identifying specific cellular markers may aid in diagnosing and potentially treating this eosinophilic syndrome.