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NERDS syndrome: an additional case report

P Zenarola1, L Melillo, M Bisceglia

  • 1Department of Dermatology, Casa Sollievo della Sofferenza' Hospital, IRCCS, S. Giovanni Rotondo, Italy.

Dermatology (Basel, Switzerland)
|January 1, 1995
PubMed
Summary
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This study details a rare eosinophilic disorder, NERDS (nodules, eosinophilia, rheumatism, dermatitis, swelling), presenting a third case. Findings highlight key clinical features and cellular changes in this unique condition.

Area of Science:

  • Rheumatology
  • Dermatology
  • Immunology

Background:

  • NERDS (nodules, eosinophilia, rheumatism, dermatitis, swelling) is a recently described eosinophilic disorder.
  • Understanding the clinical spectrum and cellular basis of NERDS is crucial for diagnosis and management.

Observation:

  • This report presents the third documented case of NERDS.
  • The patient exhibited joint and skin issues, nodules, xerosis, and recurrent urticaria with angioedema.
  • Drug-induced rash and lymphadenopathy were noted, alongside persistent leukocytosis with high eosinophil counts.

Findings:

  • Eosinophils in this case predominantly showed a hypodense phenotype, indicating activation.
  • Flow cytometry revealed a proliferation of activated CD4+/OKDR+ T helper cells and CD25+/OKDR+ eosinophils during the acute phase.

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Implications:

  • This case expands the understanding of NERDS' clinical presentation.
  • Identifying specific cellular markers may aid in diagnosing and potentially treating this eosinophilic syndrome.