Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD46-mediated measles virus entry: a first key to host-range specificity

D Gerlier1, G Varior-Krishnan, P Devaux

  • 1Laboratoire Immunité et Infections Virales, I.V.M.C. CNRS-UCBL UMR30, Faculté de Médecine Alexis Carrel, Lyon, France.

Trends in Microbiology
|September 1, 1995
PubMed
Summary

Scientists identified CD46 as a key receptor for measles virus entry into human cells. Understanding this interaction, involving moesin, is crucial for developing new strategies against measles infection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Does DC-SIGN the end of the mystery of epithelial crossing by measles virus?]

Virologie (Montrouge, France)·2022
Same author

[3D structure shed light on the efficiency of measles vaccine].

Virologie (Montrouge, France)·2022
Same author

[A cellular receptor to get in, another to get out].

Virologie (Montrouge, France)·2022
Same author

Stability of metal-organic frameworks under gamma irradiation.

Chemical communications (Cambridge, England)·2016
Same author

[Not Available].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2015
Same author

Segregation distortion and linkage studies in microspore-derived double haploid lines of Hordeum vulgare L.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013

Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Measles virus (MeV) naturally infects only humans.
  • The precise molecular mechanisms of MeV cell entry are not fully elucidated.
  • Identifying host cell receptors is critical for understanding viral tropism and pathogenesis.

Purpose of the Study:

  • To identify the cellular receptor for measles virus.
  • To investigate the molecular players involved in MeV cell entry.
  • To explore the potential for developing novel antiviral strategies.

Main Methods:

  • The study focused on identifying the measles virus receptor on human cells.
  • Investigated the role of specific cellular proteins, including CD46 and moesin, in viral entry.
  • Utilized molecular biology techniques to confirm receptor-virus interactions.

Related Experiment Videos

Main Results:

  • CD46 was identified as a functional measles virus receptor.
  • The protein moesin was shown to be involved in the measles virus entry process.
  • These findings provide insights into the molecular basis of MeV cell entry.

Conclusions:

  • CD46 is a critical host factor for measles virus infection.
  • Understanding the CD46-mediated entry pathway is essential for developing MeV vaccines and therapeutics.
  • This knowledge may facilitate the creation of animal models for studying measles pathogenesis.